Comorbid epilepsy in autism spectrum disorder: Implications of postnatal inflammation for brain excitability.
Megan Leigh LewisMitchell KeslerSydney A CandyJong M RhoQuentin J PittmanPublished in: Epilepsia (2018)
These findings suggest that an early postnatal immune challenge can increase brain excitability in adult BTBR mice and reveal an underlying epilepsy phenotype. This novel animal model may enable the elucidation of specific molecular alterations that are associated with the concurrent presentation of ASD and epilepsy, which could facilitate the development of targeted therapies for individuals affected by this comorbidity.
Keyphrases
- autism spectrum disorder
- resting state
- preterm infants
- white matter
- intellectual disability
- attention deficit hyperactivity disorder
- transcranial direct current stimulation
- oxidative stress
- functional connectivity
- genome wide
- cerebral ischemia
- single cell
- temporal lobe epilepsy
- type diabetes
- high fat diet induced
- squamous cell carcinoma
- multiple sclerosis
- young adults
- brain injury
- skeletal muscle
- wild type
- adipose tissue
- rectal cancer