LncRNA HULC augments high glucose-associated pancreatic cancer progression and drug resistance by enhancing YAP activity and autophagy.

Ankita SharmaShibasish ChowdhurySudeshna MukherjeeRajdeep Chowdhury

Published in: Biology of the cell (2024)

Inhibition of HULC and YAP may represent a novel therapeutic strategy for PDAC. Furthermore, this study portrays the intricate molecular interplay between HULC, YAP and autophagy in PDAC pathogenesis.

Keyphrases

high glucose
cell death
endothelial cells
endoplasmic reticulum stress
signaling pathway
oxidative stress
long non coding rna
single molecule