Metabolic and proteomic signatures of hypoglycaemia in type 2 diabetes.

Anna HalamaHassan KahalAditya M BhagwatJonas ZiererThozhukat Sathyapalan Johannes Graumann Karsten Suhre Stephen L Atkin

Published in: Diabetes, obesity & metabolism (2018)

The present study provides a comprehensive description of molecular events that are triggered by insulin-induced hypoglycaemia. We identified deregulated pathways in T2D that may play a role in the pathophysiology of hypoglycaemia-induced cardiovascular complications.

Keyphrases

type diabetes
glycemic control
high glucose
diabetic rats
cardiovascular disease
insulin resistance
drug induced
oxidative stress
metabolic syndrome
gene expression
endothelial cells
genome wide
dna methylation
single molecule