A novel RIP1/RIP3 dual inhibitor promoted OPC survival and myelination in a rat neonatal white matter injury model with hOPC graft.

Chu ZhangQian GuanHao ShiLingsheng CaoJing LiuZixuan GaoWenxi ZhuYinxiang YangZuo LuanRuiqin Yao

Published in: Stem cell research & therapy (2021)

The novel RIP1/RIP3 dual inhibitor ZJU-37 may promote OPC survival, differentiation and myelination by inhibiting NLRP3 inflammasome activation in a neonatal rat model of WMI with hOPC graft.

Keyphrases

nlrp inflammasome
white matter
free survival
oxidative stress
signaling pathway
multiple sclerosis