Treatment With a Three-Drug Regimen for Pulmonary Tuberculosis Based on Rapid Molecular Detection of Isoniazid Resistance: A Noninferiority Randomized Trial (FAST-TB).

Nathalie De CastroF MechaïD BacheletA CanestriV JolyM VandenhendeDavid BoutoilleM KerjouanN VezirisJ M MolinaN GrallPierre TattevinC LaouénanY Yazdanpanahnull null

Published in: Open forum infectious diseases (2022)

In a setting with low prevalence of primary isoniazid resistance, a 3-drug combination with isoniazid, rifampicin, and pyrazinamide, based on rapid detection of isoniazid resistance using molecular testing, was noninferior to starting the recommended 4-drug regimen.

Keyphrases

mycobacterium tuberculosis
pulmonary tuberculosis
adverse drug
drug induced
emergency department
combination therapy
replacement therapy