Brain-Derived Neurotrophic Factor Gene Polymorphism Predicts Response to Continuous Theta Burst Stimulation in Chronic Stroke Patients.

Shreya ParchureDenise Y HarveyPriyanka P Shah-BasakLaura DeLorettaRachel WurzmanDaniela SacchettiOlufunsho FaseyitanFalk W LohoffRoy H Hamilton

Published in: Neuromodulation : journal of the International Neuromodulation Society (2021)

Our findings strongly suggest that BDNF genotype differentially affects neuroplastic responses to TMS in individuals with chronic stroke. This provides novel insight into potential sources of variability in cTBS response in patients, which has important implications for optimizing the utility of this neuromodulation approach. Incorporating BDNF polymorphism genetic screening to stratify patients prior to use of cTBS as a neuromodulatory technique in therapy or research may optimize response rates.

Keyphrases

end stage renal disease
newly diagnosed
prognostic factors
genome wide
dna methylation
stem cells
mesenchymal stem cells
gene expression
bone marrow
working memory
patient reported
human health