Interaction of HE4 and ANXA2 exists in various malignant cells-HE4-ANXA2-MMP2 protein complex promotes cell migration.
Jing WangLu DengHuiyu ZhuangJuanjuan LiuDawo LiuXiao LiShan JinLiancheng ZhuHuimin WangBei LinPublished in: Cancer cell international (2019)
The interaction of HE4 and ANXA2 exists in various types of cancer cells. HE4 and ANXA2 can promote the proliferation, adhesion, invasion, and migration of cancer cells. HE4-ANXA2-MMP2 form a protein complex and ANXA2 plays the role of "bridge". They performed together to promote cell migration.