PIK3CA missense mutations promote glioblastoma pathogenesis, but do not enhance targeted PI3K inhibition.
Robert S McNeillEmily E StroobantErin SmithbergerDemitra A CanoutasMadison K ButlerAbigail K SheltonShrey D PatelJuanita C LimasKasey R SkinnerRyan E BashRalf S SchmidC Ryan MillerPublished in: PloS one (2018)
PIK3CAmut promoted differential gliomagenesis based on the mutated domain. While PIK3CAmut did not influence sensitivity to single agent PI3Ki, they did alter PI3Ki/MEKi synergism. Taken together, our results demonstrate that a subset of PIK3CAmut promote tumorigenesis and suggest that patients with helical domain mutations may be most sensitive to dual PI3Ki/MEKi treatment.