Can signal peptide-CUB-EGF domain-containing protein 1 (SCUBE-1) be used as an indicator of endothelial dysfunction in acromegaly patients?

Damla Tufekci Irfan Nuhoglu Sumeyye Sura Ayan Yasemin Emur Gunay Hulya Coskun Muhammet Cuneyt Bilginer Ozge Ucuncu Mustafa Kocak Serap Ozer Yaman Süleyman Caner Karahan

Published in: Endocrine (2023)

Our study revealed for the first time in literature that SCUBE-1 levels, being a novel marker for ED, were significantly higher in acromegaly patients than in control subjects. When supported with clinical studies, SCUBE-1can be used as an early indicator of endothelial damage in acromegaly patients.

Keyphrases

end stage renal disease
chronic kidney disease
ejection fraction
newly diagnosed
emergency department
prognostic factors
systematic review
oxidative stress
patient reported outcomes
small molecule
endothelial cells
protein protein
patient reported