Login / Signup

Autophagy counters inflammation-driven glycolytic impairment in aging hematopoietic stem cells.

Paul V DellorussoMelissa A ProvenFernando J Calero-NietoXiaonan WangCarl A MitchellFelix HartmannMeelad AmouzgarPatricia FavaroAndrew W DeVilbissJames W SwannTheodore T HoZhiyu ZhaoSean C BendallSean MorrisonBerthold GöttgensEmmanuelle Passegue
Published in: bioRxiv : the preprint server for biology (2023)
Autophagy compensates for chronic inflammation-induced metabolic deregulation in old HSCs, and its transient modulation can reset old HSC glycolytic and regenerative capacity.
Keyphrases
  • stem cells
  • oxidative stress
  • diabetic rats
  • cell death
  • endoplasmic reticulum stress
  • signaling pathway
  • cell therapy
  • bone marrow
  • mesenchymal stem cells
  • drug induced
  • cerebral ischemia
  • subarachnoid hemorrhage