The role of tyrosine hydroxylase-dopamine pathway in Parkinson's disease pathogenesis.
Zhi-Dong ZhouWuan Ting SawPatrick Ghim Hoe HoZhi Wei ZhangLi ZengYa Yin ChangAlfred Xu Yang SunDong Rui MaHong Yan WangLei ZhouKah Leong LimEng-King TanPublished in: Cellular and molecular life sciences : CMLS (2022)
Our findings highlight the vital role of the TH-DA pathway in PD pathogenesis. LRRK2 and PINK1 have opposing effects on the TH-DA pathway, and its balance affects DA neuron survival. LRRK2 or PINK1 mutations can disrupt this balance, promoting DA neuron demise. Our findings provide support for potential clinical trials using TH-DA pathway inhibitors in early or prodromic PD.
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