Role of autophagy in aneurysm and dissection of the ascending aorta.
Mario LusiniAntonio NennaCamilla ChelloSalvatore Matteo GrecoIlaria GagliardiFrancesco NappiMassimo ChelloPublished in: Future cardiology (2020)
Maintenance of physiologically balanced levels of autophagy is crucial for cellular homeostasis and in the normal vessel wall, balanced autophagy can be considered a cytoprotective mechanism that preserves endothelial function and prevents cardiovascular disease. Recent studies pointed out the importance of the modulation of the autophagic flux in the pathogenesis of aortic dissection and aneurysms of the ascending aorta. Notably, shear stress (and its receptor p62), IL-6, Rab7 and Atg5/IRE1α pathways of autophagy may be considered the novel super-selective therapeutic target for the preventive and postoperative treatment of aortic aneurysm and aortic dissection. This review intends to summarize current evidences in this field trying to enlighten new avenues for future researches.
Keyphrases
- aortic dissection
- cell death
- endoplasmic reticulum stress
- cardiovascular disease
- signaling pathway
- oxidative stress
- aortic aneurysm
- pulmonary artery
- type diabetes
- pulmonary arterial hypertension
- coronary artery disease
- current status
- aortic valve
- mouse model
- metabolic syndrome
- cardiovascular events
- pulmonary hypertension
- case control
- binding protein
- smoking cessation