Danzhi Jiangtang Capsule Mediates NIT-1 Insulinoma Cell Proliferation and Apoptosis by GLP-1/Akt Signaling Pathway.
Yuan-Jie WuYuan-Bo WuZhao-Hui FangMei-Qiao ChenYu-Feng WangChuan-Yun WuMing-An LvPublished in: Evidence-based complementary and alternative medicine : eCAM (2019)
DJC was able to attenuate the toxicity of high-glucose load in NIT-1 pancreatic β-cells, ascribed to the improvement of cellular proliferation and apoptosis by GLP-1/Akt signaling pathway. This study could supply a new mechanism of DJC effects on type 2 diabetes mellitus (T2DM) treatment.
Keyphrases
- signaling pathway
- cell cycle arrest
- pi k akt
- cell proliferation
- induced apoptosis
- high glucose
- endothelial cells
- epithelial mesenchymal transition
- oxidative stress
- cell death
- endoplasmic reticulum stress
- glycemic control
- cell cycle
- cardiovascular disease
- type diabetes
- adipose tissue
- cardiovascular risk factors
- weight loss