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Helical Folding of Meta-Connected Aromatic Oligoureas.

Ting HuAlan L ConnorDaniel P MillerXiao WangQiang PeiRui LiuLan HeChong ZhengEva ZurekZhong-Lin LuBing Gong
Published in: Organic letters (2017)
Aromatic oligoureas composed of meta-linked residues bearing phenolic ether side chains are synthesized. The basic N,N'-diarylurea units adopt a trans,trans intramolecularly H-bonded conformation that is further strengthened by additional intermolecular H-bonding. Such basic units, in combination with meta-linked benzene residues, result in stably folded helical oligoureas in the highly polar DMF with up to four turns and with a small cylindrical inner pore that would be difficult to acquire.
Keyphrases
  • molecular dynamics simulations
  • amino acid
  • ionic liquid
  • single molecule
  • crystal structure