FAK activates AKT-mTOR signaling to promote the growth and progression of MMTV-Wnt1-driven basal-like mammary tumors.
Ritama PaulMing LuoXueying MoJason LuSyn Kok YeoJun-Lin GuanPublished in: Breast cancer research : BCR (2020)
In summary, our studies show that in a basal-like tumor model, FAK is required for survival of the tumor cells and can serve as a potential therapeutic target.