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FAK activates AKT-mTOR signaling to promote the growth and progression of MMTV-Wnt1-driven basal-like mammary tumors.

Ritama PaulMing LuoXueying MoJason LuSyn Kok YeoJun-Lin Guan
Published in: Breast cancer research : BCR (2020)
In summary, our studies show that in a basal-like tumor model, FAK is required for survival of the tumor cells and can serve as a potential therapeutic target.
Keyphrases
  • cell proliferation
  • cell migration
  • signaling pathway
  • stem cells
  • case control
  • climate change