Androsamide, a Cyclic Tetrapeptide from a Marine Nocardiopsis sp., Suppresses Motility of Colorectal Cancer Cells.
Jihye LeeChathurika D B GamageGeum Jin KimPrima F HillmanChaeyoung LeeEun Young LeeHyukjae ChoiHangun KimSang-Jip NamWilliam FenicalPublished in: Journal of natural products (2020)
A cyclic tetrapeptide, androsamide (1), was isolated from a marine actinomycete of the genus Nocardiopsis, strain CNT-189. The planar structure of 1 was assigned by the interpretation of 1D and 2D NMR spectroscopic data. The absolute configurations of constituent amino acids of 1 were determined by application of the Marfey's and advanced Marfey's methods. Androsamide (1) strongly suppressed the motility of Caco2 cells caused by epithelial-mesenchymal transition.
Keyphrases
- epithelial mesenchymal transition
- induced apoptosis
- signaling pathway
- biofilm formation
- amino acid
- magnetic resonance
- cell cycle arrest
- molecular docking
- transforming growth factor
- high resolution
- electronic health record
- big data
- pseudomonas aeruginosa
- oxidative stress
- escherichia coli
- cell proliferation
- candida albicans