Thrombin and factor Xa link the coagulation system with liver fibrosis.

Ameet DharFouzia SadiqQuentin M AnsteeAdam P LeveneRobert D GoldinMark R Thursz

Published in: BMC gastroenterology (2018)

FXa promotes stellate cell contractility and activation. Early inhibition of coagulation using a FXa inhibitor significantly reduces TAA induced murine liver fibrosis and may be a viable treatment for liver fibrosis in patients.

Keyphrases

liver fibrosis
end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
peritoneal dialysis
single cell
cell therapy
high glucose
patient reported outcomes
bone marrow
smooth muscle
patient reported