Ex vivo propagation in a novel 3D high-throughput co-culture system for multiple myeloma.
Johannes Moritz WaldschmidtStefan J FruttigerDagmar WiderJohannes JungAndreas R ThomsenTanja N HartmannJustus DuysterMartin J HugKareem A AzabManfred JungRalph WäschMonika EngelhardtPublished in: Journal of cancer research and clinical oncology (2022)
This study introduces a novel model that is capable of long-term propagation and drug testing of primary MM specimens ex vivo overcoming some of the pitfalls of currently available in vitro models.