Gastrointestinal cancer cells treatment with bevacizumab activates a VEGF autoregulatory mechanism involving telomerase catalytic subunit hTERT via PI3K-AKT, HIF-1α and VEGF receptors.

Nadine MahfouzRoula TahtouhNada AlaaeddineJoelle El HajjRiad SarkisRay HachemIssam RaadGeorge Hilal

Published in: PloS one (2017)

Taken together, our results suggest that bevacizumab treatment activates a VEGF autoregulatory mechanism involving hTERT and VEGF receptors and that an inhibition of this pathway could improve tumor cell response to anti-VEGF treatment.

Keyphrases

vascular endothelial growth factor
endothelial cells
pi k akt
cell proliferation
stem cells
single cell
mesenchymal stem cells
cell therapy
replacement therapy
smoking cessation