Impact of age and comorbidities on SARS-CoV-2 vaccine-induced T cell immunity.
Lisa Loksø DietzAnna Karina JuhlOle Schmeltz SøgaardJoanne ReekieHenrik NielsenIsik Somuncu JohansenThomas Lars BenfieldLothar WieseNina Breinholt StærkeTomas Oestergaard JensenStine Finne JakobsenRikke OlesenKasper IversenKamille FoghJacob BodilsenKristine Toft PetersenPelle Trier PetersenLone Wulff MadsenSusan Olaf LindvigInge Kristine HoldenDorthe RabenSidsel Dahl AndersenAstrid Korning HvidtSigne Rode AndreasenEva Anna Marianne BaerendsJens Dilling LundgrenLars ØstergaardMartin Tolstrupnull nullPublished in: Communications medicine (2023)
SARS-CoV-2 Spike-specific immune responses in both the cellular and serological compartment of the adaptive immune system increase with each vaccine dose and are progressively lower with older age and higher prevalence of comorbidities. The findings contribute to the understanding of the vaccine response in individuals with increased risk of severe COVID-19 disease and hospitalization.