Proteomic Analysis Identifies Distinct Glomerular Extracellular Matrix in Collapsing Focal Segmental Glomerulosclerosis.

Michael L MerchantMichelle T BaratiDawn J CasterJessica L HataLiliane HobeikaSusan CoventryMichael E BrierDaniel W WilkeyMing LiIlse M RoodJeroen K DeegensJack F WetzelsChristopher P LarsenJonathan P TroostJeffrey B HodginLaura H MarianiMatthias KretzlerJon B KleinKenneth R McLeish

Published in: Journal of the American Society of Nephrology : JASN (2020)

ECM differences suggest that glomerular sclerosis in cFSGS differs from that in other FSGS variants. Infiltration of activated PECs may disrupt ECM remodeling in cFSGS. These cells and their cathepsins may be therapeutic targets.

Keyphrases

extracellular matrix
induced apoptosis
diabetic nephropathy
high glucose
cell cycle arrest
genome wide
copy number
oxidative stress
signaling pathway
endothelial cells
cell proliferation
dna methylation