The impact of Nrf2/HO-1, caspase-3/Bax/Bcl2 and ATF6/IRE1/PERK/GRP78 signaling pathways in the ameliorative effects of morin against methotrexate-induced testicular toxicity in rats.

Behçet VarışlıCüneyt ÇaglayanFatih Mehmet KandemirCihan Gürİbrahim BayavAydın Genç

Published in: Molecular biology reports (2022)

Treatment with morin at a dose of 50 and 100 mg/kg considerably mitigated oxidative stress, inflammation, apoptosis and endoplasmic reticulum stress in the testicular tissue indicating that testicular damage related to MT toxicity could be modulated by morin administration.

Keyphrases

endoplasmic reticulum stress
oxidative stress
induced apoptosis
diabetic rats
germ cell
ischemia reperfusion injury
dna damage
signaling pathway
pi k akt
high glucose
high dose
epithelial mesenchymal transition
cell proliferation
transcription factor
endothelial cells
stress induced