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MINAS TIRITH: a new tool for simulating radiation-induced DNA damage at the cell population level.

Yann Clément ThibautGéraldine GononJuan S Martinez GuerreroMichael PetitAurélie VaurijouxGaëtan GruelCarmen VillagrasaSebastien IncertiYann Perrot
Published in: Physics in medicine and biology (2023)
MINAS TIRITH is a new approach for the calculation of radiation-induced DNA damage at the cell population level that facilitates reasonable simulation times compared to those obtained with track structure codes. Moreover, this tool enables a more direct comparison between modeling and biological experimentation.
Keyphrases
  • radiation induced
  • dna damage
  • radiation therapy
  • single cell
  • oxidative stress
  • cell therapy
  • dna repair
  • stem cells
  • mesenchymal stem cells
  • bone marrow