Exerkine fibronectin type-III domain-containing protein 5/irisin-enriched extracellular vesicles delay vascular ageing by increasing SIRT6 stability.

Chen ChiHui FuYong-Hua LiGuo-Yan ZhangFei-Yan ZengQing-Xin JiQi-Rui ShenXu-Jie WangZi-Chen LiCan-Can ZhouDi-Yang SunJiang-Tao FuWen-Bin WuPing-Ping ZhangJia-Bao ZhangJian LiuFu-Ming ShenDong-Jie LiPei Wang

Published in: European heart journal (2022)

FNDC5/irisin-enriched EVs contribute to exercise-induced protection against vascular ageing. These findings indicate that the exerkine FNDC5/irisin may be a potential target for ageing-related vascular comorbidities.

Keyphrases

type iii
oxidative stress
ischemia reperfusion injury
amino acid
protein protein
binding protein
small molecule
human health