Diagnostic accuracy cohort study and clinical value of the Histoplasma urine antigen (ALPHA Histoplasma EIA) for disseminated histoplasmosis among HIV infected patients: A multicenter study.
Pedro Torres-GonzálezMaría Dolores Niembro-OrtegaAreli Martínez-GamboaVíctor Hugo Ahumada-TopeteJaime Federico Andrade-VillanuevaJavier Araujo-MeléndezAlberto Chaparro-SánchezBrenda Crabtree-RamírezSofia Cruz-MartínezArmando Gamboa-DomínguezOscar I Flores-BarrientosJesús Enrique Gaytán-MartínezLuz Alicia González-HernándezChristian Hernández-LeónVíctor Hugo Lozano-FernandezMarisol Manríquez-ReyesMartin Magaña-AquinoPedro Martínez-AyalaJuan Pablo Ramírez-HinojosaAndrea Rangel-CorderoNorma Erendira Rivera-MartínezEdgardo Reyes-GutiérrezGustavo Reyes-TeránPatricia Rodríguez-ZuluetaJesús Ruíz-QuiñonesJaneth Santiago-CruzNancy Guadalupe Velázquez-ZavalaJosé Sifuentes-OsornioAlfredo Ponce de León-GarduñoPublished in: PLoS neglected tropical diseases (2018)
We observed a high specificity but low sensitivity of IMMY-HUAg. The test may be useful to start early antifungals, but a culture-based approach is necessary since co-infections are frequent and a negative IMMY-HUAg result does not rule out PDH.