Cannabidiol Inhibits Inflammation Induced by Cutibacterium acnes -Derived Extracellular Vesicles via Activation of CB2 Receptor in Keratinocytes.

Ziqi JiangShanglin JinXiaoyao FanKe CaoYe LiuXuan WangYing MaLeihong Xiang

Published in: Journal of inflammation research (2022)

The results indicated that CBD could inhibit inflammation induced by CEVs in NHEKs, which was mediated by activation of CB2 receptor and enhanced by the TRPV1 antagonist, through inactivation of the MAPK and NF-κB signaling pathways. CBD might be a potential novel strategy for acne treatment in the future.

Keyphrases

signaling pathway
oxidative stress
pi k akt
induced apoptosis
epithelial mesenchymal transition
nuclear factor
lps induced
cell proliferation
binding protein
neuropathic pain
spinal cord
hidradenitis suppurativa
combination therapy
wound healing
replacement therapy
endoplasmic reticulum stress
toll like receptor