The early-life stress induced by oxytocin inhibition in p53 knockout mouse dams increases adulthood tumorigenesis in first and second generations.

Massimo StendardoChiara RenziRani PallaviNiccolò RodaValentina GambinoFrancesca CasciaroGiuseppe PersicoMarco Giorgio

Published in: Cancer reports (Hoboken, N.J.) (2022)

Therefore, the inhibition of OT function in mothers is a novel paradigm of early-life stress that is inherited across generations and increases cancer risk in tumor-prone mice.

Keyphrases

early life
stress induced
high fat diet induced
type diabetes
metabolic syndrome
insulin resistance
adipose tissue
skeletal muscle
depressive symptoms
heat stress