Akt signaling is activated by TGFβ2 and impacts tenogenic induction of mesenchymal stem cells.
Sophia K TheodossiouJett B MurrayLeeAnn A HoldJeff M CourtrightAnne M CarperNathan R SchielePublished in: Stem cell research & therapy (2021)
These findings show that Akt signaling plays a role in TGFβ2-induced tenogenesis and that tenogenesis of MSCs can be initiated by TGFβ2 during disruption of Smad3 signaling. These findings provide new insights into the signaling pathways that regulate tenogenic induction in stem cells.