Alzheimer's disease phenotypes show different sleep architecture.

Neus FalgàsChristine M WalshLeslie YackAlexander J SimonIsabel E AllenJoel H KramerHoward J RosenRenaud La JoieGil RabinoviciBruce MillerSalvatore SpinaWilliam W SeeleyKamalini RanasingheKeith VosselThomas C NeylanLea Tenenholz Grinberg

Published in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2023)

Alzheimer's disease (AD) variants show distinct patterns of sleep impairment. Amnestic/typical AD has worse N3 slow wave sleep (SWS) impairment compared to atypical AD. Atypical AD shows more rapid eye movement deficits than typical AD. Selective vulnerability patterns in subcortical areas may underlie sleep differences. Relatively preserved SWS may explain better memory scores in atypical versus typical AD.

Keyphrases

sleep quality
physical activity
traumatic brain injury
working memory
gene expression
white matter
quantum dots
loop mediated isothermal amplification