Influence of Angiotensin II on cell viability and apoptosis in rat renal proximal tubular epithelial cells in in vitro studies.
Aleksandra PiotrowskaMagdalena ChmielewskaWaldemar AndrzejewskiPiotr DziegielMarzenna Podhorska-OkolowPublished in: Journal of the renin-angiotensin-aldosterone system : JRAAS (2021)
The result of our study indicates that Ang II causes damaging effect on NRK-52E cells by directing them to programmed cell death. It seems that not only does the AT2 receptor itself play an important role in the induction of apoptosis, but also its interaction with AT1 receptor does as well.