Influence of Angiotensin II on cell viability and apoptosis in rat renal proximal tubular epithelial cells in in vitro studies.

Aleksandra Piotrowska Magdalena ChmielewskaWaldemar AndrzejewskiPiotr DziegielMarzenna Podhorska-Okolow

Published in: Journal of the renin-angiotensin-aldosterone system : JRAAS (2021)

The result of our study indicates that Ang II causes damaging effect on NRK-52E cells by directing them to programmed cell death. It seems that not only does the AT2 receptor itself play an important role in the induction of apoptosis, but also its interaction with AT1 receptor does as well.

Keyphrases

angiotensin ii
cell cycle arrest
cell death
oxidative stress
induced apoptosis
endoplasmic reticulum stress
angiotensin converting enzyme
vascular smooth muscle cells
pi k akt
signaling pathway
cell proliferation
case control