Polypharmacy, functional outcome and treatment effect of intravenous alteplase for acute ischaemic stroke.

Märit JensenF BoutitieB ChengT-H ChoM EbingerM EndresJ B FiebachJ FiehlerI FordI GalinovicA KönigsbergJ PuigP RoyA WoutersV ThijsR LemmensK W MuirNorbert NighoghossianS PedrazaC Z SimonsenC GerloffG Thomalla

Published in: European journal of neurology (2020)

In stroke patients, polypharmacy is associated with worse functional outcome after intravenous thrombolysis independent of comorbidities. However, polypharmacy does not interact with the beneficial effect of alteplase.

Keyphrases

acute ischemic stroke
high dose
adverse drug
liver failure
pulmonary embolism
aortic dissection
hepatitis b virus
replacement therapy