Clinicopathological characteristics of early onset colorectal cancer.

Fanny E R VuikStella A V NieuwenburgIris D NagtegaalErnst J Kuipers Manon C W Spaander

Published in: Alimentary pharmacology & therapeutics (2021)

EOCRC is not only characterised by age of onset but also by the more frequent presence of signet-ring cells, more poorly differentiated tumours, and higher risk of lymph node metastases. In the most recent years, a higher proportion of rectal cancer was found from the age of 30 years, and a higher proportion of CRCs were diagnosed in females below the age of 30 years.

Keyphrases

early onset
lymph node
rectal cancer
late onset
induced apoptosis
locally advanced
squamous cell carcinoma
cell cycle arrest
radiation therapy
signaling pathway
oxidative stress
early stage
cell proliferation
sentinel lymph node
pi k akt