ERC-BiP Functional Protein Pathway for Assessing Endoplasmic Reticulum Stress Induced by SARS-CoV-2 Replication after Cell Invasion.

Mingshan XueZhiwei LinTeng ZhangZhangkai J ChengRunpei LinBaojun GuoYifeng ZengFengyu HuFeng LiPeiyan ZhengHuimin HuangNing LiQi Zhao Bao-Qing Sun Xiaoping Tang

Published in: The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale (2023)

ERC-BiP can be used as a core index to reflect the degree of ER stress in COVID-19 patients, which is of great value for evaluating the functional state of cells. A functional pathway for AGT/ERC-BiP/glycolysis can directly assess the activation of unfolded protein reactions. The ERC-BiP pathway is closer to the intracellular replication pathway of SARS-CoV-2 and may help in the development of predictive protocols for COVID-19 exacerbation.

Keyphrases

sars cov
endoplasmic reticulum stress
induced apoptosis
respiratory syndrome coronavirus
coronavirus disease
chronic obstructive pulmonary disease
protein protein
small molecule
signaling pathway
binding protein
cell death
intensive care unit
reactive oxygen species
acute respiratory distress syndrome