PABPC1L Induces IDO1 to Promote Tryptophan Metabolism and Immune Suppression in Renal Cell Carcinoma.

Guannan Shu Minyu Chen Wuyuan Liao Liang-Min Fu Mingjie Lin Cheng-Peng Gui Junjie Cen Jun Lu Zhen-Hua Chen Jin-Huan Wei Wei Chen Ying-Han Wang Jiangquan Zhu Tianxin Zhao Xiao-Nan Liu Jiajia Jing Guo-Chang Liu Yihui Pan Junhang Luo Jiaxing Zhang

Published in: Cancer research (2024)

PABPC1L functions as a key factor in renal cell carcinoma immune evasion, enhancing IDO1 and impeding T-cell function, and represents a potential target to enhance the efficacy of immune checkpoint blockade therapy.

Keyphrases

renal cell carcinoma
human health
bone marrow
mesenchymal stem cells
climate change
cell therapy