Multiorgan involvement and circulating IgG1 predict hypocomplementaemia in IgG4-related disease.
Guy KatzCory PeruginoZachary S WallaceBohang JiangThomas GuyGrace A McMahonIsha JhaYuqing ZhangHang LiuAna D FernandesShiv S PillaiJohn Patterson AtkinsonAlfred Hyoungju KimJohn H StonePublished in: Annals of the rheumatic diseases (2024)
Hypocomplementaemia in IgG4-RD is not unique to patients with renal involvement and may reflect the extent of disease. IgG1 independently correlates with hypocomplementaemia in IgG4-RD, but IgG4 does not. Complement activation is likely involved in IgG4-RD pathophysiology.
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