EBV-Associated Non-keratinizing Nasopharyngeal Carcinoma with Prominent Spindled Cell and Whorling Patterns: A Previously Unreported Histological Variant in a Patient Presenting with Dermatomyositis.
Fredrik PeterssonPublished in: Head and neck pathology (2019)
A case of non-keratinizing, EBV-positive (chromogenic EBER-in situ hybridization), carcinoma with a hitherto undescribed nodular whorling architecture is presented. The patient is a 55 year old male with 2 months history of dermatomyositis who was diagnosed with T1N0M0 non-keratinizing nasopharyngeal carcinoma. The patient received radiotherapy with complete response. The tumor cells predominantly displayed spindle cell morphology, strongly expressed low-molecular weight cytokeratins (AE1-3), p63 and p40. There was no evidence of recurrence or disease progression on follow-up after 16 months which included post treatment biopsy, MRI and PET-CT scans.
Keyphrases
- pet ct
- case report
- single cell
- epstein barr virus
- interstitial lung disease
- computed tomography
- magnetic resonance imaging
- diffuse large b cell lymphoma
- radiation therapy
- contrast enhanced
- early stage
- squamous cell carcinoma
- disease activity
- systemic sclerosis
- radiation induced
- idiopathic pulmonary fibrosis
- bone marrow
- locally advanced