PNPLA3, Obesity, and Heavy Alcohol Use in Cirrhosis Patients May Exert a Synergistic Increase Hepatocellular Carcinoma Risk.

Aaron P ThriftFasiha KanwalHyeyeun LimHao DuongYanhong LiuAmit G SingalSaira KhaderiSumeet K AsraniChristopher I AmosHashem B El-Serag

Published in: Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association (2024)

The PNPLA3 variant may help refine risk stratification for HCC in patients with cirrhosis with heavy alcohol consumption or obesity who may need specific preventive measures.

Keyphrases

alcohol consumption
metabolic syndrome
insulin resistance
end stage renal disease
weight loss
type diabetes
ejection fraction
chronic kidney disease
high fat diet induced
weight gain
peritoneal dialysis
prognostic factors