Association between circulating bile acid alterations and nonalcoholic steatohepatitis independent of obesity and diabetes mellitus.

Youngae JungBo Kyung KooSeo Young JangDain KimHeeyeon LeeDong Hyeon LeeSae Kyung JooYong Jin JungJeong Hwan ParkTaekyeong YooMurim ChoiMin Kyung LeeSang Won KangMee Soo ChangWon KimGeum-Sook Hwangnull null

Published in: Liver international : official journal of the International Association for the Study of the Liver (2021)

BA metabolism is dysregulated as the histological severity of NAFLD worsens, independent of obesity and diabetes status; dysregulation is more prominent in nonobese NAFLD patients. Metabolome-driven omics approach provides new insight into our understanding of altered BA metabolism associated with individual phenotypes of NAFLD.

Keyphrases

type diabetes
insulin resistance
metabolic syndrome
weight loss
end stage renal disease
ejection fraction
newly diagnosed
weight gain
high fat diet induced
glycemic control
cardiovascular disease
peritoneal dialysis
prognostic factors
adipose tissue
skeletal muscle
body mass index