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Intratumoral injection of TLR9 agonist promotes an immunopermissive microenvironment transition and causes cooperative antitumor activity in combination with anti-PD1 in pancreatic cancer.

Carmine CarboneGeny PiroAntonio AgostiniPietro DelfinoFrancesco De SanctisVincenzo NascaFrancesco SpallottaClaudio SetteMaurizio MartiniStefano UgelVincenzo CorboPaola CappelloEmilio BriaAldo ScarpaGiampaolo Tortora
Published in: Journal for immunotherapy of cancer (2022)
We demonstrated a potent antitumor activity of IMO-2125 and anti-PD1 combination in immunotherapy-resistant PDAC models through the modulation of immune microenvironment, providing the rationale to translate this strategy into a clinical setting.
Keyphrases
  • stem cells
  • toll like receptor
  • inflammatory response
  • immune response
  • clinical trial
  • ultrasound guided