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Diagnosing type 2 diabetes using Hemoglobin A1c: a systematic review and meta-analysis of the diagnostic cutpoint based on microvascular complications.

Alexandra E ButlerEmma EnglishEric S KilpatrickLinda ÖstlundhHiam S ChemaitellyLaith J Abu-RaddadK George M M AlbertiStephen L AtkinW Garry John
Published in: Acta diabetologica (2020)
The prevalence of nephropathy and moderate retinopathy was increased in subjects with HbA1c values ≥ 6.5% confirming the high specificity of this value for diagnosing T2DM; however, at HbA1c < 6.5% retinopathy increased at age > 55 years and, most strikingly, in African-Americans, suggesting there may be excess microvascular complication prevalence (particularly nephropathy) in individuals below the diabetes diagnostic threshold.
Keyphrases
  • type diabetes
  • risk factors
  • glycemic control
  • cardiovascular disease
  • high intensity
  • weight loss
  • red blood cell