SARS-CoV-2 infections in pediatric and young adult recipients of chimeric antigen receptor T-cell therapy: an international registry report.
Kevin Owen McNerneyRebecca M RichardsPaibel Aguayo-HiraldoFriso G CalkoenJulie-An TalanoAmy MoskopAdriana BalduzziJennifer KrajewskiHema DaveAnant VatsayanColleen CallahanHongyan LiuYimei LiKara Lynn DavisShannon L MaudePublished in: Journal for immunotherapy of cancer (2023)
In a large international cohort of pediatric and young adult CAR-T recipients, SARS-CoV-2 infections resulted in frequent hospital and intensive care unit admissions and were associated with mortality in 4.3%. Patients with two or more comorbidities or aged ≥18 years were more likely to experience significant illness. Suspected Omicron infections were associated with milder disease.
Keyphrases
- sars cov
- young adults
- intensive care unit
- respiratory syndrome coronavirus
- childhood cancer
- healthcare
- kidney transplantation
- pulmonary embolism
- cardiovascular events
- type diabetes
- cardiovascular disease
- stem cells
- risk factors
- mechanical ventilation
- coronary artery disease
- mesenchymal stem cells
- bone marrow
- acute care
- extracorporeal membrane oxygenation
- smoking cessation