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SARS-CoV-2 infections in pediatric and young adult recipients of chimeric antigen receptor T-cell therapy: an international registry report.

Kevin Owen McNerneyRebecca M RichardsPaibel Aguayo-HiraldoFriso G CalkoenJulie-An TalanoAmy MoskopAdriana BalduzziJennifer KrajewskiHema DaveAnant VatsayanColleen CallahanHongyan LiuYimei LiKara Lynn DavisShannon L Maude
Published in: Journal for immunotherapy of cancer (2023)
In a large international cohort of pediatric and young adult CAR-T recipients, SARS-CoV-2 infections resulted in frequent hospital and intensive care unit admissions and were associated with mortality in 4.3%. Patients with two or more comorbidities or aged ≥18 years were more likely to experience significant illness. Suspected Omicron infections were associated with milder disease.
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