An Exonic Switch Regulates Differential Accession of microRNAs to the Cd34 Transcript in Atherosclerosis Progression.

Miguel HuesoJosep M CruzadoJoan TorrasEstanislao Navarro

Published in: Genes (2019)

We introduce new potential mediators of ATH progression (CD34 cell-clusters, miR-351), and propose a new mechanism of miRNA action, linked to a cryptic splicing site in the target-host gene, that would regulate the differential accession of miRNAs to their cognate binding sites.

Keyphrases

cell proliferation
long non coding rna
single cell
rna seq
cell therapy
genome wide
copy number
long noncoding rna
heat shock
gene expression
dna methylation
climate change
transcription factor
heat stress
genome wide analysis