Taxodikaloids A and B, Two Dimeric Abietane-Type Diterpenoids from Taxodium ascendens Possessing an Oxazoline Ring Linkage.
Xing-Hao HuangLing-Xue TaoChang-Qiang KeChunping TangHai-Yan ZhangYang YeLi-Gen LinSheng YaoPublished in: Organic letters (2017)
Two dimeric diterpenoids, taxodikaloids A (1) and B (2), have been identified from the seeds of Taxodium ascendens. The diterpenoid structures were established on the basis of comprehensive spectroscopic analysis, and the absolute configuration of taxodikaloid A (1) was further confirmed by single-crystal X-ray diffraction. Both structures feature an unprecedented oxazoline ring linkage connecting two abietane diterpenoid monomers. A plausible biosynthetic pathway for compounds 1 and 2 is proposed. Both compounds show potential neuroprotective activity against Aβ25-35-induced damage in SH-SY5Y cells.
Keyphrases
- high resolution
- induced apoptosis
- genome wide
- cell cycle arrest
- oxidative stress
- hiv testing
- molecular docking
- diabetic rats
- high glucose
- machine learning
- deep learning
- cell death
- endoplasmic reticulum stress
- dual energy
- computed tomography
- endothelial cells
- risk assessment
- human immunodeficiency virus
- subarachnoid hemorrhage
- pi k akt
- contrast enhanced