Cytotoxicity on low-grade canine meningioma with the use of somatostatin analog (octreotide): An in vitro study.

Maria Teresa MandaraAlessia TognoloniGiuseppe GigliaMassimo BaroniCristian FalzonePietro CalòElisabetta Chiaradia

Published in: Neuro-oncology advances (2024)

Octreotide reduced the alive neoplastic cultured cells of low-grade canine meningioma in a dose-dependent pattern with continuous exposition for 48 hours. These results support an alternative systemic treatment of meningioma with octreotide in the dog.

Keyphrases

low grade
neuroendocrine tumors
high grade
optic nerve
induced apoptosis
cell cycle arrest
endothelial cells
endoplasmic reticulum stress
cell death
signaling pathway