Eupatilin attenuates TGF-β2-induced proliferation and epithelial-mesenchymal transition of retinal pigment epithelial cells.

Ayca Kupeli Cinar Sadik Altan Ozal Riza Serttas Suat Erdogan

Published in: Cutaneous and ocular toxicology (2021)

These results suggest that eupatilin could inhibit the proliferation and transformation into fibroblast-like cells of RPE cells; thus the agent may be a potential therapeutic value in treating PVR.

Keyphrases

epithelial mesenchymal transition
signaling pathway
induced apoptosis
transforming growth factor
cell cycle arrest
high glucose
pi k akt
diabetic rats
endoplasmic reticulum stress
drug induced
oxidative stress
cell death
endothelial cells