Novel personalized cancer vaccine platform based on Bacillus Calmette-Guèrin.
Erkko O YlösmäkiManlio FuscielloBeatriz MartinsSara FeolaFiras HamdanJacopo ChiaroLeena YlösmäkiMatthew J VaughanTapani ViitalaPrasad S KulkarniVincenzo CerulloPublished in: Journal for immunotherapy of cancer (2022)
This study shows that intratumoral BCG immunotherapy can be improved by coating the bacteria with modified tumor-specific peptides. In addition, this improved BCG immunotherapy can be combined with ICI therapy to obtain enhanced tumor growth control. These results warrant clinical testing of this novel cancer vaccine platform.