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Mechanisms involved in the cytotoxic action of Brazilian propolis and caffeic acid against HEp-2 cells and modulation of P-glycoprotein activity.

Lívia M da SilvaYahima Frión-HerreraAriane R BartolomeuCarolina Mendonça GorgulhoJosé Maurício Sforcin
Published in: The Journal of pharmacy and pharmacology (2017)
Propolis exerted cytotoxic effects on HEp-2 cells, and the mechanisms are discussed, showing its potential as an antitumour drug.
Keyphrases
  • induced apoptosis
  • cell cycle arrest
  • endoplasmic reticulum stress
  • oxidative stress