Hyperthermia promotes exosome secretion by regulating Rab7b while increasing drug sensitivity in adriamycin-resistant breast cancer.

Di Xu Wen-Juan Tang Yi-Zhi Zhu Zhen Liu Kai Yang Ming-Xing Liang Xiu Chen Yang Wu Jin-Hai Tang Wei Zhang

Published in: International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group (2022)

Our results demonstrated a novel function of hyperthermia in promoting exosome secretion in adriamycin-resistant breast cancer cells and revealed the effects of hyperthermia on tumor cell biology. These hyperthermia-triggered exosomes can carry antitumor genes to the residual tumor and tumor microenvironment, which may be more beneficial to the effects of hyperthermia. These results represent an exploration of the relationship between therapeutic strategies and exosome biology.

Keyphrases

breast cancer cells
single cell
stem cells
mesenchymal stem cells
genome wide
emergency department
cell therapy
gene expression
bone marrow
drug induced