Insulin signaling accelerates the anterograde movement of Rab4 vesicles in axons through Klp98A/KIF16B recruitment via Vps34-PI3Kinase.

Kamaldeep Singh Semanti Das Sabyasachi Sutradhar Jonathon Howard Krishanu Ray

Published in: bioRxiv : the preprint server for biology (2024)

Dilp2-mediated insulin signaling activates anterograde transport of Rab4 vesiclesVps34 regulates anterograde velocity, run length and flux of Rab4 vesiclesLocal PI(3)P signaling on Rab4 vesicles regulates their motility in the axonsPI(3)P production upon acute insulin stimulation recruits Klp98A on Rab4 vesicles.

Keyphrases

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