Multifunctional nanozyme-reinforced copper-coordination polymer nanoparticles for drug-resistance bacteria extinction and diabetic wound healing.
Jiahui ZhaoTengfei XuJichao SunHaitao YuanMengyun HouZhijie LiJigang WangZhen LiangPublished in: Biomaterials research (2023)
The Cu-CPNs@EPL complex has impressive antioxidant properties and antibacterial effects, making it a promising solution for treating drug-resistant bacterial infections in chronic wounds. The complex's ability to neutralize multiple ROS and reduce ROS-induced inflammation can help relieve inflammation at the wound site. Schematic illustration of the ROS scavenging and bacteriostatic function induced by Cu-CPNs@EPL nanozyme in the treatment of MRSA-infected wounds.
Keyphrases
- wound healing
- drug resistant
- oxidative stress
- dna damage
- cell death
- reactive oxygen species
- multidrug resistant
- diabetic rats
- acinetobacter baumannii
- metal organic framework
- staphylococcus aureus
- drug delivery
- methicillin resistant staphylococcus aureus
- high glucose
- aqueous solution
- type diabetes
- anti inflammatory
- drug induced
- cancer therapy
- pseudomonas aeruginosa
- combination therapy
- replacement therapy
- smoking cessation
- walled carbon nanotubes